GT-Plex™ ESR1 Panel

GT-Plex™ ESR1 Panels

Identify nine common ESR1 mutations and a wild-type ESR1 target within a single well using our patent-pending multiplexed digital PCR (dPCR) technology (RUO). Breast cancer is one of the most common cancers worldwide, with approximately 75% of all breast cancer cases measuring positive and receiving endocrine therapy. The most common mutations for treatment resistance are in the estrogen receptor 1 (ESR1) gene.

Research Use Only (RUO). Not intended for diagnostic purposes. Contact us for assay kit availability on more platforms!

ESR1 Digital PCR Mutation Panel for the Roche Digital LightCycler® System

Highly multiplexed assay measures 9 ESR1 mutations and a wild-type ESR1 target within a single well
Patent-pending technology allows for highly specific detection and quantification
Kits include controls and step-by-step data analysis guidance
Assay detects key ESR1 mutations in ctDNA even in very low concentration plasma samples

For research use only. Not intended for diagnostic use.

GT-Plex™ Multiplexed ESR1 Panel

ESR1 Mutation Panel
Specifically designed to target the following common ESR1 mutations: E380Q, S463P, L536H/R/P, Y537C/S/N, and D538G

Highly Sensitive
Detect as few as 3 target copies per reaction

Robust
Eliminate interference from PCR inhibitors compared to real-time quantitative PCR (RT-qPCR)

High Throughput
Multiplex for faster throughput and lower reagent cost

Compatible
Use with formalin-fixed paraffin-embedded (FFPE), liquid biopsy, fresh/frozen tissue, cell-free DNA (cfDNA), circulating tumor (ctDNA), and low-yield samples

GT-Plex™ Multiplex Digital PCR Assays Show Robust Performance Across a Broad Linear Dynamic Range

Get Our App Notes

Our ESR1 Oncology Assays Are Optimized for the Roche Digital PCR Platform with More in Development!

Roche Digital LightCycler® System

Key Benefits

Sensitive

Detect as few as 3 copies of the ESR1 gene per reaction and genotype samples with low nucleic acid concentrations

Multiplexed

Leverage our GT-Plex™ technology to amplify more targets in each assay, saving you time and money

Easy to Use

Assay your samples with validated kits that include all necessary primers, probes, and controls

Robust

Minimize interference from PCR inhibitors using dPCR technology

Popular Oncology Research Kits

GT-Digital ESR1 Mutation Panel v1.0 for the Roche Digital LightCycler™ System

(Cat# 100805) A Research-Use Only (RUO) and patent-pending molecular reagent kit comes fully equipped with all the necessary primers, probes, and controls to detect and quantify common mutations in the human ESR1 gene linked to breast cancer. Our comprehensive multi-target kit includes one assay solution and two qualitative controls, specifically designed to target the following […]

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dPCR EGFR Actionable Mutations Panel Assay Kit for the Bio-Rad QX200®

(Cat# 100435) The dPCR EGFR Actionable Mutations Panel Assay Kit for the Bio-Rad QX200® Droplet Digital® PCR System is a Research-Use Only (RUO) patent-pending molecular reagent kit containing all primers, probes, and controls for the detection and relative abundance of common activating mutations found in the human EGFR gene. Contains enough material for 50 reactions.

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GT-Digital IDH1/IDH2/NPM1 Mutation Panel v1.0 for the Roche Digital LightCycler™ System

(Cat# 100730) The GT-Digital IDH1/IDH2/NPM1 Mutation Panel for the Roche Digital LightCycler™ System is a Research-Use Only (RUO), patent-pending molecular reagent kit containing all primers, probes, and controls for the detection and relative abundance of common mutations found in the human IDH1, IDH2, and NPM1 genes. This multi-target kit contains one assay solution and three […]

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Quantify Your Target in 3 Easy Steps

Receive

Receive kit via overnight shipping within five business days

Process

Extract nucleic acid from your sample using your lab’s preferred method

Assay

Perform the PCR assay on your sample using your instrument of choice

GT Molecular dPCR Assay Advantages

Increased Sensitivity

Detect low-copy number transcripts with greater sensitivity than RT-qPCR

Multiplex Technology

Assay several targets in each dPCR reaction, saving you time and money

Decreased Inhibitor Interference

Small reactions dilute the effects of any PCR inhibitors present in a sample

FAQs

What instruments can I use with the GT-Plex™ Multiplex dPCR Kits?

GT-Plex™ Multiplex dPCR Kits are compatible with the QIAGEN QIAcuity™, Roche Digital LightCycler®, and Bio-Rad QX100™, QX200™, and QX600™ dPCR platforms.

Do you offer technical support?

Yes! GT Molecular’s technical support scientists are available from 8:00am to 5:00pm (MT) Monday through Friday to answer any questions regarding our products. Contact us at 1 970-498-1698 or through this form, and we’ll be happy to walk you through the workflow and answer any questions you may have.

Which targets are measured by the GT-Plex™ ESR1 Multiplex PCR Kit?

The GT-Plex™ ESR1 Multiplex PCR Kit covers 9 common ESR1 mutations including the following: E380Q, S463P, L536H/R/P, Y537C/S/N, and D538G

To ensure precision and reliability, the kit also provides a wild-type ESR1 control and a 10% mutant control. Contains enough material for 50 reactions.

What positive controls are used with the GT-Plex™ ESR1 Multiplex PCR Kit?

To ensure precision and reliability, the kit also provides a wild-type ESR1 control and a 10% mutant control.

How soon after placing an order can I expect delivery of the kit?

Once an order is placed, most assay kits are shipped within 5 business days on ice via FedEx Priority Overnight.

What sample types can be used with the GT-Plex™ ESR1 Multiplex PCR Kit?

Our oncology research kits are suitable for use with formalin-fixed paraffin-embedded (FFPE) tissues, liquid biopsy, fresh/frozen tissue, cell-free DNA (cfDNA), circulating tumor DNA (ctDNA), and low-yield samples. Our dPCR assays also tolerate samples that contain PCR inhibitors.